منابع مشابه
Looking Down , Around , and Up : Mechanistic
Accounts of mechanistic explanation have emphasized the importance of looking down—decomposing a mechanism into its parts and operations. Using research on visual processing as an exemplar, I illustrate how productive such research has been. But once multiple components of a mechanism have been identified, researchers also need to figure out how it is organized—they must look around and determi...
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Children with trisomy 21/DS represent a clinically and genetically unique subset of pediatric patients with AML, with patients ,4 years of age having a 500-fold increased risk of developing the disease. Taub et al report improved event-free survival and overall survival in a prospective cohort of children with DS that examined the impact of early intensification of cytarabine therapy and reduct...
متن کاملLooking down, around, and up: Mechanistic explanation in psychology
Accounts of mechanistic explanation have emphasized the importance of looking down— decomposing a mechanism into its parts and operations. Using research on visual processing as an exemplar, I illustrate how productive such research has been. But once multiple components of a mechanism have been identified, researchers also need to figure out how it is organized—they must look around and determ...
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Down’s syndrome (DS) is the most common aneuploidy diagnosed in liveborn babies ( 1/700 live births). While DS is typically associated with recognizable dysmorphic features, clinical anomalies exhibit variable expressivity. The DS phenotype includes many organ systems and affects all three embryonic germ layers. DS is the most frequent chromosomal cause of mental retardation, is a recognized ge...
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Remote sensing platforms can collect measurements on a global scale within a few days, which provides an unprecedented opportunity to characterize and understand the spatio-temporal variability of environmental variables. Because of the additional challenges of making precise and accurate measurements from space, it is essential to validate satellite remote sensing datasets with highly precise ...
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ژورنال
عنوان ژورنال: Nature
سال: 2001
ISSN: 0028-0836,1476-4687
DOI: 10.1038/35102648